About Cupid-Psyche System
CompleCure's AMDC technology uses two innovative molecules, “Cupid” and “Psyche”, which are low-immunogenic modified streptavidins developed to precisely target cancer cells. Psyche can bind therapeutic ingredients such as anti-cancer drugs and photosensitizers as payloads to deliver drugs to cancer cells in a targeted manner.
Psyche is a computationally designed molecule that forms strong bonds with Cupid.
Cupid Features
Cupid is a protein composed of an antibody that specifically binds to a cancer antigen, a linker, and modified streptavidin. The protein is synthesized in *E. coli* from a gene sequence encoding the antibody, linker, and modified streptavidin as a single fusion protein. The modified streptavidin allows Cupid to form a tetramer and bind to cancer cells at four distinct sites, thereby enhancing binding stability.
Psyche Features
Psyche can conjugate drugs at the terminus of an extended linker.
These linkers can be efficiently conjugated via click chemistry.
Currently, Psyche is conjugated with various payloads, including anti-cancer drugs, photosensitizers, and radionuclides.
AMDC Features
Allows for rational drug design by selecting specific combinations of Cupid and Psyche.
